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In this thesis, the three-component reactions of N-cinnamylidene aniline derivatives as an nucleophile with acetylenic diester in the presence of N,N’-diphenyl parabanic acid in dichloromethane (DCM) under reflux condition are reported which led to 1,3-oxazine derivatives in good to high yields.
Also, the antibacterial activities of 4-chloro-N-cinnamylidene aniline and some of the produced 1,3-oxazines against four bacterial species has been investigated. The results exhibited good antibacterial activity for imine, but the 1,3-oxazines didn’t display any antibacterial activity.
Three-component reactions, N-cinnamyliden aniline derivatives, N,N’-diphenyl parabanic acid, acetylenic ester, antibacterial activities.
University of Mazandaran
Faculty of chemistry
Proposed for MSc Degree in Organic Chemistry
Tree-component synthesis of spiro 1,3-oxazines using conjugated imines, acetylenic esters and activated carbonyl compounds and study of their biological activities
Dr. Sakineh Asghari
Dr. Robabeh Baharfar
Danial Alizadeh
February 2015
1 Aldimine
2 Ketimine
3 Anil
4 Schiff base
5 Hugo schiff
6 Carbinol
7 Ritter
8 Reddelien
9 Arthur Hantzsch
10 Staphylococcus aureus
11 Bacillus subtilis
12 Escherichia coli
13 Pseudomonasa aeruginosa
14 Prokaryotes
15 Gram staining
16 Crystal Violet
17 Peptidoglycan
18 Safranin
19 Gentamicin
20 Kirbi-Bauer
21 Mueller-Hinton agar
22 Swab
23 Zone of growth inhibition

مطلب مرتبط :   منبع پایان نامه دربارهمعنادار بودن، سطح معنادار، اندازه شرکت

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