HIV-RT and thrombin. Pure and Applied Chemistry, 71 (11), 2025-2030.
63. He, P., Wu, J., Nie, Y. B., & Ding, M. W. (2009). New efficient synthesis of 4-aminocarbonyl substituted 4H-3, 1-benzoxazines by a Passerini 3CC/Staudinger/aza-Wittig sequence. Tetrahedron, 65 (41), 8563-8570.
64. Hutt, A. G., & O’Grady, J. (1996). Drug chirality: a consideration of the significance of the stereochemistry of antimicrobial agents. Journal of Antimicrobial Chemotherapy, 37(1), 7-32.
65. Polk, R. E. (1982). Moxalactam (moxam, eli-lilly). Drug Intelligence & Clinical Pharmacy, 16(2), 104-112.
66. Narisada, M., Yoshida, T., Onoue, H., Ohtani, M., Okada, T., Tsuji, T., … & Satoh, H. (1979). Synthetic studies on β-lactam antibiotics. Part 10. Synthesis of 7β-[2-carboxy-2-(4-hydroxyphenyl) acetamido]-7. alpha.-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl) thio] methyl]-1-oxa-1-dethia-3-cephem-4-carboxylic acid disodium salt (6059-S) and its related 1-oxacephems. Journal of medicinal chemistry, 22(7), 757-759.
67. Palmer, B. D., Thompson, A. M., Sutherland, H. S., Blaser, A., Kmentova, I., Franzblau, S. G., … & Denny, W. A. (2009). Synthesis and Structure− Activity Studies of Biphenyl Analogues of the Tuberculosis Drug (6 S)-2-Nitro-6-{[4-(trifluoromethoxy) benzyl] oxy}-6, 7-dihydro-5 H-imidazo [2, 1-b][1, 3] oxazine (PA-824). Journal of medicinal chemistry, 53(1), 282-294.
68. Bollo, S., Núñez-Vergara, L. J., Kang, S., Zhang, L., Boshoff, H. I., Barry III, C. E., … & Dowd, C. S. (2011). The effect of 5-substitution on the electrochemical behavior and antitubercular activity of PA-824. Bioorganic & medicinal chemistry letters, 21(2), 812-817.
69. Cherian, J., Choi, I., Nayyar, A., Manjunatha, U. H., Mukherjee, T., Lee, Y. S., … & Barry III, C. E. (2011). Structure–Activity Relationships of Antitubercular Nitroimidazoles. 3. Exploration of the Linker and Lipophilic Tail of ((S)-2-Nitro-6, 7-dihydro-5 H-imidazo [2, 1-b][1, 3] oxazin-6-yl)-(4-trifluoromethoxybenzyl) amine (6-Amino PA-824). Journal of medicinal chemistry, 54(16), 5639-5659.
70. Karadogan, B., & Parsons, P. J. (2001). Synthesis of racemic brevioxime and related analogues. Tetrahedron, 57(41), 8699-8703.
71. Clive, D. L., & Hisaindee, S. (2000). Synthesis of racemic brevioxime and related model compounds. The Journal of organic chemistry, 65(16), 4923-4929.
72. Moya, P., Castillo, M., Primo-Yúfera, E., Couillaud, F., Martínez-Máñez, R., Garcerá, M. D., … & Martínez-Pardo, R. (1997). Brevioxime: a new juvenile hormone biosynthesis inhibitor isolated from Penicillium brevicompactum. The Journal of Organic Chemistry, 62(24), 8544-8545.
73. Augelli-Szafran, C. E., Jaen, J. C., Moreland, D. W., Nelson, C. B., Penvose-Yi, J. R., & Schwarz, R. D. (1998). Identification and characterization of m4 selective muscarinic antagonists. Bioorganic & Medicinal Chemistry Letters,8(15), 1991-1996.
74. Xu, W., Zhang, S., Yang, S., Jin, L. H., Bhadury, P. S., Hu, D. Y., & Zhang, Y. (2010). Asymmetric synthesis of α-aminophosphonates using the inexpensive chiral catalyst 1, 1’-binaphthol phosphate. Molecules, 15(8), 5782-5796.
75. Bekdemir, Y., & Efil, K. (2014). Microwave Assisted Solvent-Free Synthesis of Some Imine Derivatives. Organic Chemistry International, 2014.
76. Ulrich, H., & Sayigh, A. A. R. (1965). The reaction of oxalyl chloride with substituted ureas and thioureas. The Journal of Organic Chemistry, 30(8), 2781-2783.
77. Ercan, F., Öztas, S. G., Ancm, N., Hökelek, T., Tüzün, M., & Ülkü, D. (1996). Structural and spectral studies of N-trans-cinnamylidene-m-toluidine and N-trans-cinnamylidene-m-chloroaniline. Journal of Chemical Crystallography, 26(3), 243-247.
78. M. A. E1-Bayotimi, M. EJ-Asser & F. Abdel-Halirn, (1971). Journal of the American Chemical Society, 93, 586-590.
In this thesis, the three-component reactions of N-cinnamylidene aniline derivatives as an nucleophile with acetylenic diester in the presence of N,N’-diphenyl parabanic acid in dichloromethane (DCM) under reflux condition are reported which led to 1,3-oxazine derivatives in good to high yields.
Also, the antibacterial activities of 4-chloro-N-cinnamylidene aniline and some of the produced 1,3-oxazines against four bacterial species has been investigated. The results exhibited good antibacterial activity for imine, but the 1,3-oxazines didn’t display any antibacterial activity.
Three-component reactions, N-cinnamyliden aniline derivatives, N,N’-diphenyl parabanic acid, acetylenic ester, antibacterial activities.
University of Mazandaran
Faculty of chemistry
Proposed for MSc Degree in Organic Chemistry
Tree-component synthesis of spiro 1,3-oxazines using conjugated imines, acetylenic esters and activated carbonyl compounds and study of their biological activities
Dr. Sakineh Asghari
Dr. Robabeh Baharfar
Danial Alizadeh
February 2015
1 Aldimine
2 Ketimine
3 Anil
4 Schiff base
5 Hugo schiff
6 Carbinol
7 Ritter
8 Reddelien
9 Arthur Hantzsch
10 Staphylococcus aureus
11 Bacillus subtilis
12 Escherichia coli
13 Pseudomonasa aeruginosa
14 Prokaryotes
15 Gram staining
16 Crystal Violet
17 Peptidoglycan
18 Safranin
19 Gentamicin
20 Kirbi-Bauer
21 Mueller-Hinton agar
22 Swab
23 Zone of growth inhibition

مطلب مرتبط :   پایان نامه با کلمات کلیدیآسیب‌شناسی، دندانپزشکی، دانشگاه علوم پزشکی

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